Bioequivalence and Bioavailability Forum • Definition of Full Replicate

Definition of Full Replicate [Design Issues]

posted by Achievwin – US, 2023-03-27 21:08 (1186 d 02:06 ago) – Posting: # 23513
Views: 9,074

Dear Experts

Can TRT, RTR be called two sequence full replicate in three way cross over? can it be a substitute for RTRT or TRTR, or TTRR or RRTT (in four period fully replicated design)?

The goal is to do a 3-period cross-over yet to capture ISCV for Test and Reference separately. Can this type of design address RSABE for warfarin by FDA?

(Nothing) Achievwin :-D

Complete thread:

Definition of Full Replicate Sereng 2023-03-13 17:08
- Definition of Full Replicate Mahmoud 2023-03-13 20:27
  - Definition of Full Replicate Sereng 2023-03-13 23:38
    - Definition of Full Replicate Mahmoud 2023-03-14 08:44
      - Definition of Full ReplicateAchievwin 2023-03-27 19:08
        
        Full Replicate with 3 periods mittyri 2023-03-27 22:16
        
        Full Replicate with 3 periods Achievwin 2023-03-28 03:06
        Full Replicate with 3 periods Helmut 2023-03-28 09:03
- Definition of Full Replicate Brus 2023-03-14 10:10
- Replicate Design ≠ Higher-Order Crossover Helmut 2023-03-14 10:37
  - Thank You! Sereng 2023-03-14 20:08
  - Replicate Design ≠ Higher-Order Crossover Relaxation 2023-03-20 08:56
    - imbalance in Latin Square mittyri 2023-03-27 23:01
    - Balance for all effects Helmut 2023-04-21 10:01