Bioequivalence and Bioavailability Forum

Drug-drug interaction with two different route of administration [Design Issues]

posted by Mr.Rao – India, 2022-07-27 10:31 (1418 d 10:03 ago) – Posting: # 23182
Views: 5,912

Dear All,

from below reference link they are concluded there is no clinically relevant drug–drug interaction between CHF 5993 and result of cimetidine co-administration, with total exposure increased by 16 %, and peak concentration by 26 %.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340825/

I need to know how they concluded.

Looking forward to hear in details.

Thansk,

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! Why didn’t you ignore Ohlbe’s note? [Helmut]

Complete thread:

Drug-drug interaction with two different route of administration Mr.Rao 2022-07-13 13:51
- Drug-drug interaction with two different route of administration Mr.Rao 2022-07-14 09:05
  - Drug-drug interaction with two different route of administration dshah 2022-07-20 10:27
    - Drug-drug interaction with two different route of administration Mr.Rao 2022-07-21 11:24
      - Drug-drug interaction with two different route of administration dshah 2022-07-21 18:51
        
        Drug-drug interaction with two different route of administration Mr.Rao 2022-07-22 07:23
        
        Drug-drug interaction with two different route of administrationMr.Rao 2022-07-27 08:31
        
        Interpreting results of a DDI study Helmut 2022-07-27 09:52

Drug-drug interaction with two different route of admi­nistration [Design Issues]

Complete thread:

Drug-drug interaction with two different route of administration [Design Issues]