PK time points [Design Issues]

posted by Vaibhav – India, 2022-06-23 23:31 (1455 d 14:53 ago) – Posting: # 23077
Views: 4,265

Dear All,
Are the below sampling points adequate for PK profile?
Median Tmax - 6 days
Mean half life: 26 days
Sub cutaneous: single dose
2, 12 and 24 hrs after administration. Additional samples were collected on day 2, 4, 6, 8, 10, 14, 28, 42, 56, 84, 112 and 140 days.
I have taken these time points from an article available in public domain.
Is there any method to calculate sampling point apart from method mentioned in BABE guidelines?
It’s a difficult to calculate time points for drug who has long Tmax and long half life.
Thank you in advance.


Edit: Category changed; see also this post #1[Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
23,654 posts in 4,992 threads, 1,571 registered users;
158 visitors (0 registered, 158 guests [including 15 identified bots]).
Forum time: 14:25 CEST (Europe/Vienna)

“Data! Data! Data!” he cried impatiently.
“I can’t make bricks without clay!”    Arthur Conan Doyle

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5