Bioequivalence and Bioavailability Forum • 2.220446e-16 ≈ 0

2.220446e-16 ≈ 0 [Design Issues]

posted by PharmCat – Russia, 2019-12-24 15:18 (2369 d 06:12 ago) – Posting: # 21025
Views: 12,193

❝ ❝ ❝ For observation 8 we have -3.608225e-16, I think,

❝ ❝ I think, is around the "effective zero" for fits in R at default settings on 64- and 32-bit systems.

Hi Helmut!

I suppose hat this value come from QR decomposition with pivoting of rank deficient X matrix. So real value = 0. Can residual of random variable be equal zero? - No => bias.

Complete thread:

Should those subjects have only one period data be included in BE analysis? ssussu 2019-12-06 10:58
- No way! But... Beholder 2019-12-06 12:36
  - No way! But... ElMaestro 2019-12-06 13:14
    - No way! But... Helmut 2019-12-06 14:47
      - No way! But... PharmCat 2019-12-06 23:46
        
        No way! But... wienui 2019-12-07 04:01
        
        EMA guideline: no way...: mittyri 2019-12-07 20:58
        
        EMA guideline: no way...: wienui 2019-12-09 05:25
        
        Slightly off topic, but related :-) ElMaestro 2019-12-08 01:31
        
        Slightly off topic, but related :-) Shuanghe 2019-12-09 12:00
        Slightly off topic, but related :-) PharmCat 2019-12-09 15:13
        
        Slightly off topic, but related :-) ElMaestro 2019-12-21 15:02
        
        Slightly off topic, but related :-) PharmCat 2019-12-22 01:12
        2.220446e-16 ≈ 0 Helmut 2019-12-22 10:37
        
        The optional tolerance argument ElMaestro 2019-12-23 14:37
        2.220446e-16 ≈ 0PharmCat 2019-12-24 14:18
        
        Sum of residuals ~ ε Helmut 2019-12-24 14:54
        
        Sum of residuals ~ ε ElMaestro 2019-12-24 15:10
        
        Wrong terminology Helmut 2019-12-28 13:55
        
        Sum of residuals ~ ε PharmCat 2019-12-24 18:40