Bioequivalence and Bioavailability Forum • Not sure whether it makes sense

Not sure whether it makes sense [Design Issues]

posted by abhimanyu – Banglore, 2019-08-03 15:54 (2111 d 00:53 ago) – Posting: # 20469
Views: 4,106

Hi Helmut/SP,

❝ Maybe it is better to opt for a modified Williams’ design T₁T₂RR | T₂RT₁R | RT₁RT₂ | RRT₂T₁ which gives

❝ T₁•RR | •RT₁R | RT₁R• | RR•T₁ and

❝ •T₂RR | T₂R•R | R•RT₂ | RRT₂•

❝ At least balanced for T₁ and T₂ (once in every period).

❝ However, we have R twice in periods 1&2 and only once in periods 3&4.

If we consider modified Williams’ design with this sequence T1T2RR | T2RT1R | RT1RT2 | RRT2T1 Then,

What would be change in Proc GlM / Proc Mixed for Calculate Swr, 95% Upper bound (Scaled), and 90% CI (Unscaled) :confused:

.

Thanking you in advance!! :-)

—
Abhimanyu

Complete thread:

suggest suitable Sequence for Reference replicate and Two Different Test? SP 2019-07-29 14:31
- Not sure whether it makes sense Helmut 2019-07-29 17:25
  - Not sure whether it makes senseabhimanyu 2019-08-03 13:54
    - Not sure whether it makes sense d_labes 2019-08-03 19:35
      - Not sure whether it makes sense abhimanyu 2019-08-05 09:27