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RegisterSteady State design [Design Issues]
Dear Sir/Madam,
I have some doubts in designing study state protocols.
Example: Tamsulosin
how to fix number of days to dosing
how to fix number of doses per day
My regular practice is if label/smpc states achievement of steady-state concentrations by the fifth day of once-a-day dosing for Tamsulosin, i will design the study state protocol with once a day dosing for five days. but i want to know the exact scientific rationale behind this.
please help me...
Regards,
Rajasekhar
Edit: Category changed; see also this post #1. [Helmut]
I have some doubts in designing study state protocols.
Example: Tamsulosin
how to fix number of days to dosing
how to fix number of doses per day
My regular practice is if label/smpc states achievement of steady-state concentrations by the fifth day of once-a-day dosing for Tamsulosin, i will design the study state protocol with once a day dosing for five days. but i want to know the exact scientific rationale behind this.
please help me...
Regards,
Rajasekhar
Edit: Category changed; see also this post #1. [Helmut]
Complete thread:
- Steady State designrajasekharkakarla 2018-05-03 12:28
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 5–7 predominant half lives Helmut 2018-05-03 14:12
Ing. Helmut Schütz