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Hi Javier,
I don't know the reason of using this metric in the article you're reading.
But I would cite a classic one1
![[image]](img/uploaded/image149.jpg)
So you don't need MD data to get Vss. By the way be aware! Only bolus/infusion data are apllicable (see here)
1. Gibaldi M, D Perrier D. Pharmacokinetics. New York: Marcel Dekker; 2nd ed. 1982
I don't know the reason of using this metric in the article you're reading.
But I would cite a classic one1
So you don't need MD data to get Vss. By the way be aware! Only bolus/infusion data are apllicable (see here)
1. Gibaldi M, D Perrier D. Pharmacokinetics. New York: Marcel Dekker; 2nd ed. 1982
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- Volume of distribution in steady state and Bioequivalence javier 2016-09-14 16:18
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Volume of distribution in steady state and Bioequivalence BE-proff 2016-09-15 13:45
- Vss definitionmittyri 2016-09-15 14:33
- Vss definition javier 2016-09-21 16:39
Ing. Helmut Schütz