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RegisterVolume of distribution in steady state and Bioequivalence [Design Issues]
Hi again!
After more time than I would have liked to see, Im coming back to the forum with one question about BE studies
I was reading an article about PK study single dose Healthy volunteers comparing the two drugs,and I was surprised by the Vdss as one pharmacokinetic parameter to match Bioequivalence
I thought Steady state is more appropriate for a multiple dose study, when you can observe the steady state equilibrium (after 3-5 half lives)
So if someone can enlighten about it, i would appreciate it very much
Kinds regards
Javier
After more time than I would have liked to see, Im coming back to the forum with one question about BE studies
I was reading an article about PK study single dose Healthy volunteers comparing the two drugs,and I was surprised by the Vdss as one pharmacokinetic parameter to match Bioequivalence
I thought Steady state is more appropriate for a multiple dose study, when you can observe the steady state equilibrium (after 3-5 half lives)
So if someone can enlighten about it, i would appreciate it very much
Kinds regards
Javier
Complete thread:
- Volume of distribution in steady state and Bioequivalencejavier 2016-09-14 16:18
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Volume of distribution in steady state and Bioequivalence BE-proff 2016-09-15 13:45
- Vss definition mittyri 2016-09-15 14:33
- Vss definition javier 2016-09-21 16:39
Ing. Helmut Schütz