Bioequivalence and Bioavailability Forum • incomplete ≠ sparse

incomplete ≠ sparse [Design Issues]

posted by Helmut – Vienna, Austria, 2015-10-14 17:14 (3911 d 13:45 ago) – Posting: # 15562
Views: 6,231

Hi Mahesh,

the paper should be read in conjunction with:

Yan Z. Comments on ‘Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs’. Stat Med. 2013;32(30):5484–6. doi 10.1002/sim.5995
Jaki T, Pallmann P, Wolfsegger MJ. Authors' reply to Comments on ‘Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs’. Stat Med. 2013;32(30);5487–8. doi 10.1002/sim.6000

The paper deals with AUC_0-t where only a few sampling time points are missing from a complete (rich) data set. In their example only one (prior to t_max) was missing. The paper does not deal with C_max. IMHO, the method is not applicable to a “sparse sample design”.

However, Thomas and Martin are members of the forum. They are by far more qualified than I am. ;-)

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Complete thread:

sparse sample design Mahesh M 2015-10-14 12:03
- sparse sampling ⇒ population PK Helmut 2015-10-14 12:51
  - sparse sampling ⇒ population PK Mahesh M 2015-10-14 13:55
    - incomplete ≠ sparseHelmut 2015-10-14 15:14