Bioequivalence and Bioavailability Forum

Hyoscine N-butyl­bromide 10mg Flim-Coated vs Sugar Coated [Design Issues]

posted by nobody – 2015-03-04 09:01 (4126 d 03:10 ago) – Posting: # 14544
Views: 18,751

Hi Mei!

Other examples N-butyl scopolamine, trospium chloride, easy to find in Pubmed, just a very few hits

Especially for trospium there is some older data indicating nightmare, while there is a recently published BE study indicating a CVintra of only about 16%, that sounds to good to be true, I would not base my sample size estimate on that

There seems to be active transport involved in the GI-absorption of these compounds...

Have fun!

Complete thread:

• Hyoscine N-butyl­bromide 10mg Film-Coated vs Sugar Coated Mei San 2015-03-03 04:45 
  • Hyoscine N-butyl­bromide 10mg Film-Coated vs Sugar Coated Dr_Dan 2015-03-03 10:20
    • Hyoscine N-butyl­bromide 10mg Flim-Coated vs Sugar Coated nobody 2015-03-03 16:27
      • Hyoscine N-butylbromide 10mg Film-Coated vs Sugar Coated Mei San 2015-03-04 03:26
        • Hyoscine N-butyl­bromide 10mg Flim-Coated vs Sugar Coatednobody 2015-03-04 08:01
    • Hyoscine N-butyl­bromide 10mg Film-Coated vs Sugar Coated Mei San 2015-03-04 03:32
      • Hyoscine N-butylbromide 10mg Film-Coated vs Sugar Coated nobody 2015-03-04 09:20
  • reformulate Dr_Dan 2015-03-04 08:56