Bioequivalence and Bioavailability Forum

Hyoscine N-butylbromide 10mg Film-Coated vs Sugar Coated [Design Issues]

posted by Mei San – Malaysia, 2015-03-04 04:32 (4132 d 13:19 ago) – Posting: # 14543
Views: 18,910
(edited on 2015-03-04 08:41)

Dear Dr Dan,

I've performed the CDP at pH 1.2,4.5, 6.8 and the F2 values calculated were 31.7, 33, 32.42 respectively. Definitely the film-coated tablet release is faster than sugar-coated tablet. Thus, still lack of confidence to proceed for the BE, taking into consideration the absorption variability and low detection amount. Is there anything I've missed out?

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Dr_Dan]

Complete thread:

Hyoscine N-butylbromide 10mg Film-Coated vs Sugar Coated Mei San 2015-03-03 04:45
- Hyoscine N-butylbromide 10mg Film-Coated vs Sugar Coated Dr_Dan 2015-03-03 10:20
  - Hyoscine N-butylbromide 10mg Flim-Coated vs Sugar Coated nobody 2015-03-03 16:27
    - Hyoscine N-butylbromide 10mg Film-Coated vs Sugar Coated Mei San 2015-03-04 03:26
      - Hyoscine N-butylbromide 10mg Flim-Coated vs Sugar Coated nobody 2015-03-04 08:01
  - Hyoscine N-butylbromide 10mg Film-Coated vs Sugar CoatedMei San 2015-03-04 03:32
    - Hyoscine N-butylbromide 10mg Film-Coated vs Sugar Coated nobody 2015-03-04 09:20
- reformulate Dr_Dan 2015-03-04 08:56

Hyoscine N-butyl­bromide 10mg Film-Coated vs Sugar Coated [Design Issues]

Complete thread:

Hyoscine N-butylbromide 10mg Film-Coated vs Sugar Coated [Design Issues]