Bioequivalence and Bioavailability Forum • DDI active wash-out

DDI active wash-out [Design Issues]

posted by Dr_Dan – Germany, 2015-01-09 16:59 (4183 d 18:21 ago) – Posting: # 14268
Views: 9,331

Dear nobody
You are completely right, but my question is a little bit different. I start my my study with Treatment C, 5 days dosing drug 1 = steady state drug 1. Next step Treatment B, 14 days dosing drug 2 = steady state drug 2. Then I will administer the combination product. But for how long? For drug 1 I need 5 days and for drug 2 I am already at steady state. If I consider the formulation effect I would need to dose 14 days, but is this necessary?
Kind regards
Dr_Dan

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Kind regards and have a nice day
Dr_Dan

Complete thread:

drug-drug interaction in steady state? Dr_Dan 2014-12-08 17:31
- DDI only in steady state Helmut 2014-12-08 17:43
  - DDI only in steady state Dr_Dan 2014-12-08 18:15
    - DDI only in steady state Helmut 2014-12-08 18:30
      - DDI only in steady state felipeberlinski 2014-12-18 17:37
        
        DDI only in steady state Helmut 2014-12-18 17:59
      - DDI only in steady state Dr_Dan 2015-01-07 15:42
        
        DDI active wash-out Dr_Dan 2015-01-09 12:04
        
        DDI active wash-out nobody 2015-01-09 15:03
        DDI active wash-outDr_Dan 2015-01-09 15:59
        
        DDI active wash-out nobody 2015-01-09 16:38