Bioequivalence and Bioavailability Forum • DDI active wash-out

DDI active wash-out [Design Issues]

posted by nobody – 2015-01-09 16:03 (4188 d 16:52 ago) – Posting: # 14267
Views: 9,487

The wash-out in a DDI study should depend on the effect you expect (from prior knowledge, such as in vitro data etc.). For a PK interaction, wash-out based on PK might be sufficient, if you expect induction or irreversible inhibition (metabol. enzymes, transporters), then things might be a little different.

Example:

rifampicin

—
Kindest regards, nobody

Complete thread:

drug-drug interaction in steady state? Dr_Dan 2014-12-08 17:31
- DDI only in steady state Helmut 2014-12-08 17:43
  - DDI only in steady state Dr_Dan 2014-12-08 18:15
    - DDI only in steady state Helmut 2014-12-08 18:30
      - DDI only in steady state felipeberlinski 2014-12-18 17:37
        
        DDI only in steady state Helmut 2014-12-18 17:59
      - DDI only in steady state Dr_Dan 2015-01-07 15:42
        
        DDI active wash-out Dr_Dan 2015-01-09 12:04
        
        DDI active wash-outnobody 2015-01-09 15:03
        DDI active wash-out Dr_Dan 2015-01-09 15:59
        
        DDI active wash-out nobody 2015-01-09 16:38