Bioequivalence and Bioavailability Forum • Prolonged release: washout

Prolonged release: washout [Design Issues]

posted by AngusMcLean – USA, 2014-12-29 16:29 (4198 d 15:53 ago) – Posting: # 14202
Views: 9,190

I think that it is not always a great idea to have an assay with highest sensitivity. Calculate about 5% of the Cmax and use that as a target figure for lower limit of assay quantitation. What you cannot see cannot hurt you.

"no"; there is no formal guideline for washout period: The washout period for your drug should be ~10 half lives. For clinic convenience ~5 days. People often leave 1 week for their own convenience.

Angus

Complete thread:

Prolonged release: sampling time and washout calculation mittyri 2014-12-21 17:52
- Prolonged release: sampling time and washout calculation ElMaestro 2014-12-21 20:38
- Prolonged release: sampling time and washout calculation AngusMcLean 2014-12-21 23:00
- Predominant t½ Helmut 2014-12-22 02:43
  - Prolonged release: updated data mittyri 2014-12-28 16:37
    - Prolonged release: updated data ElMaestro 2014-12-28 17:23
      - Prolonged release: updated data mittyri 2014-12-29 07:57
    - Prolonged release: updated data AngusMcLean 2014-12-29 00:00
      - Prolonged release: washout mittyri 2014-12-29 08:32
        
        Prolonged release: washoutAngusMcLean 2014-12-29 15:29
        
        Prolonged release: thanks mittyri 2014-12-29 21:11