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RegisterTwo fully replicated designs? [Design Issues]
posted by Helmut 
– Vienna, Austria, 2014-12-27 16:52 (4202 d 06:52 ago) – Posting: # 14180
Views: 20,372
Hi Kumar,
I think that all these “designs” lead to trouble. I would suggest two fully replicated three-period designs.
A fully replicated design gives you not only the variability of R but also of T. If the variance of T is lower than the one R you will get a reward in the pivotal study (smaller sample size).
Decision(s):
I think that all these “designs” lead to trouble. I would suggest two fully replicated three-period designs.
T1 R T1 and T2 R T2
R T1 R R T2 R
A fully replicated design gives you not only the variability of R but also of T. If the variance of T is lower than the one R you will get a reward in the pivotal study (smaller sample size).
Decision(s):
- Select the test which is closer to R.
- If there are no substanial differences between tests, select the less variable one.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Two Tests with Same Reference Noha Abdeljawad 2012-11-27 08:18
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Crossover designs with more than 2 treatments d_labes 2012-11-27 09:51
- Crossover designs with more than 2 treatments Noha Abdeljawad 2012-11-29 07:43
- Sounds wrong to me ElMaestro 2012-11-27 12:10
- Sounds wrong to me Dr_Dan 2012-11-27 14:32
- Sounds wrong to me Noha Abdeljawad 2012-11-29 07:52
- Two Tests with Same Reference jag009 2012-11-28 21:26
- FDA & multiplicity Helmut 2012-11-30 14:04
- FDA & multiplicity jag009 2012-11-30 15:16
- FDA & multiplicity Helmut 2012-11-30 16:12
- FDA & multiplicity jag009 2012-11-30 22:47
- FDA & multiplicity Helmut 2012-12-01 02:00
- FDA & multiplicity jag009 2012-12-03 21:53
- FDA & multiplicity Helmut 2012-12-01 02:00
- FDA & multiplicity jag009 2012-11-30 22:47
- FDA & multiplicity Helmut 2012-11-30 16:12
- Multiplicity: Mixed feelings ElMaestro 2012-11-30 15:24
- Multiplicity: Mixed feelings Helmut 2012-11-30 15:52
- Multiplicity: Mixed feelings martin 2012-12-03 09:24
- Multiplicity: Mixed feelings kumarnaidu 2013-12-12 11:03
- More infos, please Helmut 2013-12-12 15:27
- Multiplicity: Mixed feelings Helmut 2012-11-30 15:52
- FDA & multiplicity jag009 2012-11-30 15:16
- Two Tests with Same Reference Noha Abdeljawad 2012-12-03 08:29
- Two Tests with Same Reference jag009 2012-12-03 15:35
- X-way d_labes 2012-12-04 09:25
- design kvgreddy06 2013-12-19 15:32
- design kvgreddy06 2013-12-30 16:48
- design intuitivepharma 2013-12-31 06:44
- design kumarnaidu 2013-12-31 08:24
- Problematic design Helmut 2013-12-31 15:02
- Problematic design kvgreddy06 2014-01-03 14:46
- Problematic design kumarnaidu 2014-12-24 12:56
- Problematic design Helmut 2014-12-24 16:10
- Problematic design kumarnaidu 2014-12-26 05:38
- Two fully replicated designs?Helmut 2014-12-27 15:52
- Problematic design kumarnaidu 2014-12-26 05:38
- Problematic design Helmut 2014-12-24 16:10
- Problematic design Helmut 2013-12-31 15:02
- design kumarnaidu 2013-12-31 08:24
- design intuitivepharma 2013-12-31 06:44
- design kvgreddy06 2013-12-30 16:48
- design kvgreddy06 2013-12-19 15:32
- X-way d_labes 2012-12-04 09:25
- Two Tests with Same Reference jag009 2012-12-03 15:35
- FDA & multiplicity Helmut 2012-11-30 14:04
- Crossover designs with more than 2 treatments d_labes 2012-11-27 09:51
Ing. Helmut Schütz