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RegisterVital signs: based on PD [Design Issues]
posted by Helmut 
– Vienna, Austria, 2014-12-09 03:22 (4218 d 04:06 ago) – Posting: # 14027
Views: 5,641
Hi cher0424,
Not directly. It depends on the pharmacodynamic (effect) profile. Some IR-formulations have an early tmax and an intermediate t½, but the onset of effect might be ≫tmax and effects last much longer than what you would expect from the PK-profile.
No rule is the rule. Check the literature about the drug’s PD.
❝ […] Is it just relate to Cmax and AUC?
Not directly. It depends on the pharmacodynamic (effect) profile. Some IR-formulations have an early tmax and an intermediate t½, but the onset of effect might be ≫tmax and effects last much longer than what you would expect from the PK-profile.
No rule is the rule. Check the literature about the drug’s PD.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:
- Vital signs check time design cher0424 2014-12-09 01:24
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Vital signs: based on PDHelmut 2014-12-09 02:22
- Vital signs: based on PD cher0424 2014-12-09 03:35
- Panto = safe Helmut 2014-12-09 03:50
- Panto = safe cher0424 2014-12-09 04:02
- Panto = safe Helmut 2014-12-09 03:50
- Vital signs: based on PD cher0424 2014-12-09 03:35
- Vital signs: based on PDHelmut 2014-12-09 02:22
Ing. Helmut Schütz