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Registerblood sample collection design [Design Issues]
Dear all,
i have a confusion
while working with nitroglycerin 0.6mg SL Tablets regarding blood sample time points design, please suggest me in this way.
Nitroglycerin = mean elimination half-life of 2 to 3 minutes.
Half-life values range from 1.5 to 7.5 minutes.
this drug having 2 major metabolites 1,2- and 1,3-dinitroglycerin, are found in plasma.
Mean peak 1,2- and 1,3-dinitroglycerin plasma concentrations occur at approximately 15 minutes postdose.
The elimination half-life of 1,2- and 1,3-dinitroglycerin is 36 and 32 minutes, respectively.
the overall half life and peack plasma concentration is in minutes only so please sujjest me the designing of sample timepoints.
i have a confusion
while working with nitroglycerin 0.6mg SL Tablets regarding blood sample time points design, please suggest me in this way.Nitroglycerin = mean elimination half-life of 2 to 3 minutes.
Half-life values range from 1.5 to 7.5 minutes.
this drug having 2 major metabolites 1,2- and 1,3-dinitroglycerin, are found in plasma.
Mean peak 1,2- and 1,3-dinitroglycerin plasma concentrations occur at approximately 15 minutes postdose.
The elimination half-life of 1,2- and 1,3-dinitroglycerin is 36 and 32 minutes, respectively.
the overall half life and peack plasma concentration is in minutes only so please sujjest me the designing of sample timepoints.
Complete thread:
- blood sample collection designbharathnadh.pharma 2014-11-21 12:56
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