Bioequivalence and Bioavailability Forum • Subject selection

Subject selection [Design Issues]

posted by ele2008 – Korea, 2014-10-23 07:25 (4267 d 08:43 ago) – Posting: # 13772
Views: 28,063
(edited on 2014-10-23 10:55)

Thank you for the intriguing discussion.

I posted this issue because my professor proposed we conduct such a study: to attest whether this genotype-dependancy of WSV exists or not, and if it does exist, is it same for different CYP enzymes?

So his original intention was to reduce WSV (and hence the sample size) by recruiting genetically-homogeneous subjects.

However, after reading the discussion, I wonder if it is still worth doing so (my first question).

Currently, what I am doing is to search for references and to find out if WSV is genotype-dependent. Because there are not so many papers, I decided to find papers on drug-drug interaction (DDI) studies which included genetic information. Because I read your lecture that says WSV can also be estimated from DDI studies.

But I wonder how different this estimation is from their real WSV that is determined from a replicate study or a BE study (my second question).

I appreciate very much all opinions and comments here, also if you are interested in participating our study or have any better ideas, please feel free to share with me.

Edit: I removed your e-mail address and activated the link to the contact form in your profile. [Helmut]

Complete thread:

Subject selection ele2008 2014-10-16 05:06
- Genotyping in BE Helmut 2014-10-16 15:04
  - Genotyping in BE ele2008 2014-10-16 16:18
    - Genotyping in BE nobody 2014-10-16 17:43
      - Genotyping in BE Helmut 2014-10-16 18:13
        
        Genotyping in BE nobody 2014-10-16 18:24
        
        Any experiences? Helmut 2014-10-17 19:30
        
        Any experiences? nobody 2014-10-17 20:04
        
        Any experiences? Helmut 2014-10-18 15:04
        
        Any experiences? nobody 2014-10-20 08:06
        
        Any experiences? Helmut 2014-10-20 13:00
        
        Any experiences? nobody 2014-10-20 14:21
- Subject selectionele2008 2014-10-23 05:25
  - Subject selection ele2008 2014-10-23 16:47
    - Subject selection ElMaestro 2014-10-23 17:25
      - Subject selection nobody 2014-10-23 17:53
    - Editing posts Helmut 2014-10-23 17:54
    - ♀ on a mission? Helmut 2014-10-23 19:50