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RegisterTwo stage design in a 4 way crossover fasting-fed BE study [Design Issues]
Dear Helmut,
Is it possible to have a two-stage design in a 4-way crossover study (involving fasting and fed of both R and T) if variability observed between the two conditions differ pointing to 2 different sample sizes for fasting and fed.
Suppose fasting reuires 60 subjects and fed requires 100 subjects, do we have to dose 100 subjects intoto or to separate the sample sizes?
Kind regards,
Tina
Is it possible to have a two-stage design in a 4-way crossover study (involving fasting and fed of both R and T) if variability observed between the two conditions differ pointing to 2 different sample sizes for fasting and fed.
Suppose fasting reuires 60 subjects and fed requires 100 subjects, do we have to dose 100 subjects intoto or to separate the sample sizes?
Kind regards,
Tina
Complete thread:
- 4x4-fasting-fed study beman 2014-04-04 13:48
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 4x4-fasting-fed study Helmut 2014-04-04 14:00
- Two stage design in a 4 way crossover fasting-fed BE studyTina 2014-05-16 10:35
- TSD: 2 cross-overs Helmut 2014-05-16 12:03
- Two stage design in a 4 way crossover fasting-fed BE studyTina 2014-05-16 10:35
- 4x4-fasting-fed study Dr_Dan 2014-04-04 19:44
- 4x4-fasting-fed study Tina 2014-05-16 12:31
- 4x4-fasting-fed study Helmut 2014-04-04 14:00
Ing. Helmut Schütz