Bioequivalence and Bioavailability Forum

design [Design Issues]

posted by kvgreddy06 – India, 2013-12-30 17:48 (4558 d 14:19 ago) – Posting: # 12114
Views: 22,192

Dear All,

kindly provide which one is possible and advantages, disadvantages.

design,
Test product (A)
Test Product (B)
Reference Product (C)
here i am using reference product twice,

* : Three treatment, four period, four sequences crossover reference replicated


**: Three treatment, four period Three sequences, crossover reference replicated




Among those which one is suitable, or any other one

one of my friend suggesting **:
study is a reference replicate study with two test treatment and the analysis will be done separately for both the test product by using the sequences ACC, CAC and CCA for test product A and BCC, CBC and CCB for test product B which is derived from the original sequences ABCC ,CABC & CCAB . However the derived sequences met the criteria of classical reference replicate study design and sequence (TRR, RRT and RTR) and the same number of sequence order will not be able to generate from the four sequences.

Thanku..

Complete thread:

• Two Tests with Same Reference Noha Abdeljawad 2012-11-27 08:18 
  • Crossover designs with more than 2 treatments d_labes 2012-11-27 09:51
    • Crossover designs with more than 2 treatments Noha Abdeljawad 2012-11-29 07:43
  • Sounds wrong to me ElMaestro 2012-11-27 12:10
    • Sounds wrong to me Dr_Dan 2012-11-27 14:32
    • Sounds wrong to me Noha Abdeljawad 2012-11-29 07:52
  • Two Tests with Same Reference jag009 2012-11-28 21:26
    • FDA & multiplicity Helmut 2012-11-30 14:04
      • FDA & multiplicity jag009 2012-11-30 15:16
        • FDA & multiplicity Helmut 2012-11-30 16:12
          • FDA & multiplicity jag009 2012-11-30 22:47
            • FDA & multiplicity Helmut 2012-12-01 02:00
              • FDA & multiplicity jag009 2012-12-03 21:53
      • Multiplicity: Mixed feelings ElMaestro 2012-11-30 15:24
        • Multiplicity: Mixed feelings Helmut 2012-11-30 15:52
          • Multiplicity: Mixed feelings martin 2012-12-03 09:24
        • Multiplicity: Mixed feelings kumarnaidu 2013-12-12 11:03
          • More infos, please Helmut 2013-12-12 15:27
    • Two Tests with Same Reference Noha Abdeljawad 2012-12-03 08:29
      • Two Tests with Same Reference jag009 2012-12-03 15:35
        • X-way d_labes 2012-12-04 09:25
          • design kvgreddy06 2013-12-19 15:32
            • designkvgreddy06 2013-12-30 16:48
              • design intuitivepharma 2013-12-31 06:44
                • design kumarnaidu 2013-12-31 08:24
                  • Problematic design Helmut 2013-12-31 15:02
                    • Problematic design kvgreddy06 2014-01-03 14:46
                    • Problematic design kumarnaidu 2014-12-24 12:56
                      • Problematic design Helmut 2014-12-24 16:10
                        • Problematic design kumarnaidu 2014-12-26 05:38
                          • Two fully repli­cated designs? Helmut 2014-12-27 15:52