Bioequivalence and Bioavailability Forum

Dear Alex
Sorry, but I am not sure if I can follow your thoughts. Just for clarification, I guess your treatments are not systemically available, right? (otherwise they could not be administered simultanously) You are planning a Pilot study with a three way cross-over design, right? In each period you have 4 subjects but three pairs of simultaneous application which leads to imbalances, right?

Subjects in rows
1: T1+C; T2+C; T1+T2
2: T2+C; T1+C; T1+T2
3: T1+T2; T1+C; T2+C
4: T1+C; T1+T2; T2+C

Treatments/Period in columns
3xT1; 3xT1; 2xT2
2xT2; 2xT2; 4xT2
3xC; 3xC; 2xC

each Treatment occurs 8 times

Please correct me if I am wrong.
Kind regards
Dan