Bioequivalence and Bioavailability Forum

Dear ElMaestro,

Thank you for the reply.

Does biological half life affect plasma concentration? What happens if a drug having greater tissue distribution redistributes to the plasma? Would not considering biological halflife not affect Cmax of period 2 (if redistribution occurs!)? Should we not assess the safety of the subjects throughout the wasout of the biological half life period?

Thanks in advance for the guidance.

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Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]