Biological Half Life and plasma half life-Washout period [Design Issues]

posted by Tina – India, 2013-04-20 09:09 (4817 d 21:55 ago) – Posting: # 10442
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What is the difference between plasma half life and biological half life?

If for a product the plasma half life is 3h while biological half life is 30h, do I need to consider biological half life for the wasout period?

Considering differences in half life, will there be differences in the other PK parameters as well--biological Tmax! biological Cmax! biological AUC!

What is the relation between Tmax and halflife? What are the properties of a product with lesser Tmax and higher half life and viceversa?
:confused:

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