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RegisterHush hush baby [Design Issues]
Dear d_labes,
This, I think, does not look right; e.g. lower left and upper right should be identical; I would possibly put rho*sbT*sbR top right if the solution with rho is desired. I never understand why we want a rho but what do I really know?!?
The zeros elsewhere applies whenever two observations are from different subjects. Note that I speak of V (=ZGZt+R), rather than G or R alone. Anyways, for the case of three treatments (2 R's and one T) V will, assuming data are ordered by subject, have such blocks as you suggest diagonally and zeros elsewhere.
❝ I would expect some inter-subject (co)variance terms on each off-diagonal element like that for 'normal' replicate designs, f.i. partial replicate (written for the sequence TRR, heterogeneous compound symmetry parametrization):
❝ T R R
❝ T s2bT + s2wT rho*sbT*sbR s2bR
❝ R rho*sbT*sbR s2bR + s2wR s2bR
❝ R rho*sbT*sbR s2bR s2bR + s2wR
❝ s2bT=between variance of T, s2wT=within variance of T, sbT=sqrt(s2bT)
❝ s2bR=between variance of R, s2wR=within variance of R, sbR=sqrt(s2bR)
This, I think, does not look right; e.g. lower left and upper right should be identical; I would possibly put rho*sbT*sbR top right if the solution with rho is desired. I never understand why we want a rho but what do I really know?!?
The zeros elsewhere applies whenever two observations are from different subjects. Note that I speak of V (=ZGZt+R), rather than G or R alone. Anyways, for the case of three treatments (2 R's and one T) V will, assuming data are ordered by subject, have such blocks as you suggest diagonally and zeros elsewhere.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Highly variable drugs of different dosage forms Ken Peh 2013-04-05 14:00
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Highly variable drugs of different dosage forms jag009 2013-04-05 15:46
- Highly variable drugs of different dosage forms Ken Peh 2013-04-05 20:26
- Two tests, one ref, replicate for ref for possiblescaling. ElMaestro 2013-04-05 17:37
- Two tests, one ref, replicate for ref for possiblescaling. Ken Peh 2013-04-05 20:23
- Hush hush ElMaestro 2013-04-06 00:28
- Hush hush baby d_labes 2013-04-08 11:57
- Hush hush babyElMaestro 2013-04-08 12:23
- VarCov typo d_labes 2013-04-08 16:50
- Hush hush babyElMaestro 2013-04-08 12:23
- Hush hush baby d_labes 2013-04-08 11:57
- T1-T2-R-R d_labes 2013-04-08 09:10
- Hush hush ElMaestro 2013-04-06 00:28
- Two tests, one ref, replicate for ref for possiblescaling. Ken Peh 2013-04-05 20:23
- Highly variable drugs of different dosage forms jag009 2013-04-05 15:46
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