Bioequivalence and Bioavailability Forum • Two tests, one ref, replicate for ref for possiblescaling.

Two tests, one ref, replicate for ref for possiblescaling. [Design Issues]

posted by ElMaestro – Denmark, 2013-04-05 19:37 (4831 d 17:00 ago) – Posting: # 10358
Views: 7,908

Hello Ken,

❝ We can run a 3-way crossover study comparing a test product in different dosage forms (capsule and tablet) and a reference product.

❝

❝ For highly variable drug, we need to carry out replicate design, either partial or full replicate. How to fit one reference product and one test product in different dosage forms into replicate design ? Any idea ? :confused:

If I get you right, then Test(Caps)-Test(Tabs)-Ref-Ref and (a subset of) permutations thereof will work.

Provided that I haven't misunderstood the latest trends in sequence coding defined by possible descendants of Ötzi this is equivalent (no pun intended) to Hocus(Caps)-Hocus(Tabs)-Pocus-Pocus or something like that plus permutations.

—
Pass or fail!
ElMaestro

Complete thread:

Highly variable drugs of different dosage forms Ken Peh 2013-04-05 14:00
- Highly variable drugs of different dosage forms jag009 2013-04-05 15:46
  - Highly variable drugs of different dosage forms Ken Peh 2013-04-05 20:26
- Two tests, one ref, replicate for ref for possiblescaling.ElMaestro 2013-04-05 17:37
  - Two tests, one ref, replicate for ref for possiblescaling. Ken Peh 2013-04-05 20:23
    - Hush hush ElMaestro 2013-04-06 00:28
      - Hush hush baby d_labes 2013-04-08 11:57
        
        Hush hush baby ElMaestro 2013-04-08 12:23
        
        VarCov typo d_labes 2013-04-08 16:50
    - T1-T2-R-R d_labes 2013-04-08 09:10