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RegisterBE study – 3×6 design [Regulatives / Guidelines]
Dear Manu,
Due to the nature of a crossover design you need not to worry about present period effects. Regarding the multiplicity adjustment: Not sure, but if you want to go ahead with both test treatments later on, then I believe one should adjust for that. For example, the overall power (product of the two powers from both comparisons) should be 90%. (Side note: Although the third comparison is not of interest here, I wonder whether this one may affect our overall power ...)
Best regards,
Ben
Due to the nature of a crossover design you need not to worry about present period effects. Regarding the multiplicity adjustment: Not sure, but if you want to go ahead with both test treatments later on, then I believe one should adjust for that. For example, the overall power (product of the two powers from both comparisons) should be 90%. (Side note: Although the third comparison is not of interest here, I wonder whether this one may affect our overall power ...)
Best regards,
Ben
Complete thread:
- BE study – 3×6 design manu126 2012-09-14 08:33
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- BE study – 3×6 designBen 2012-09-17 17:32
Ing. Helmut Schütz