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RegisterIncorporation of Dose in statistical Model [Regulatives / Guidelines]
Hello Pash,
I must admit that I also find it a little weird.
The drug is dosed according to the approximate surface area. If you wish to include dose in the stats model it must be absolute dose rather than dose divided by area (expressed as mg/m2 will be the same across all subjects). Absolute dose then comes in as a covariate, I guess. But as you say, for each subject the absolute dose will be the same in both periods within any subject. So I can't imagine inclusion of dose achieves much.
I guess (and I literally mean this is a guess) that the model is:
y=intercept+Seq+Subj+Trt+Per+Dose, where the first four are fixed factors and the last one is a covariate. Or...?
I must admit that I also find it a little weird.
The drug is dosed according to the approximate surface area. If you wish to include dose in the stats model it must be absolute dose rather than dose divided by area (expressed as mg/m2 will be the same across all subjects). Absolute dose then comes in as a covariate, I guess. But as you say, for each subject the absolute dose will be the same in both periods within any subject. So I can't imagine inclusion of dose achieves much.
I guess (and I literally mean this is a guess) that the model is:
y=intercept+Seq+Subj+Trt+Per+Dose, where the first four are fixed factors and the last one is a covariate. Or...?
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Incorporation of Dose in statistical Model pash413 2012-04-06 14:56
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Incorporation of Dose in statistical ModelElMaestro 2012-04-07 13:07
Ing. Helmut Schütz