Bioequivalence and Bioavailability Forum • 5x5-crossover study with 12 subjects

5x5-crossover study with 12 subjects - sequences [Regulatives / Guidelines]

posted by beman – 2012-03-13 14:12 (5223 d 07:24 ago) – Posting: # 8262
Views: 6,860

First of all: thank you all for your response

@Elmaestro: you wrote down ecactly my thoughts.

@Dr_Dan: 5x5, because sponsor have some reason for that. 3x3 is in that case not possible

@HS:
10 Sequences are suficient to reach first-order balcaned design. Usually /Often carry-over effect result in predose-values >LLOQ. Wash-out phase is choosen long enough.

10 sequences:

0 1 4 2 3
1 2 0 3 4
2 3 1 4 0
3 4 2 0 1
4 0 3 1 2
3 2 4 1 0
4 3 0 2 1
0 4 1 3 2
1 0 2 4 3
2 1 3 0 4

@d_labes:

your 5x5 latin square, combined with 15 subjects would fit to, if we assume, that there is no carry-over effect. But i am not shure, which of these both approaches (5 vs. 10) sequences is the better one.

Complete thread:

5x5-crossover study with 12 subjects - sequences beman 2012-03-12 14:23
- 5x5-crossover study with 12 subjects - sequences ElMaestro 2012-03-12 14:55
- 5x5-crossover study with 12 subjects - sequences Dr_Dan 2012-03-12 15:25
  - 5x5-crossover study with 12 subjects - sequences beman 2012-03-12 15:38
    - 5x5-crossover study with 12 subjects - sequences Dr_Dan 2012-03-13 10:59
- 5x5-crossover study with 12 subjects - sequences Helmut 2012-03-12 22:31
  - 12 d_labes 2012-03-13 10:32
  - 5x5-crossover study with 12 subjects - sequences ElMaestro 2012-03-13 11:47
    - Questions over questions d_labes 2012-03-13 13:08
      - ok then lemme explain ElMaestro 2012-03-13 13:26
        
        ok then lemme explain d_labes 2012-03-13 15:03
      - Questions over questions ElMaestro 2012-03-13 15:45
    - 5x5-crossover study with 12 subjects - sequencesbeman 2012-03-13 13:12
  - 5x5-crossover study with 12 subjects - sequences beman 2012-03-13 13:25