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My dear Ol' pirate,
don't get your point.
Why do you favour a Williams design (balanced or not) BEman has in mind over a simpler Latin square design as I suggested or a much simpler incomplete block design with less periods than treatments which Helmut suggested as one possibility, which BTW addresses your concern "the risk of dropouts"?
Why do you think this is a "... big theoretical problem ..."? Because its more unusual and lesser known then what's called Williams design everybody who had some notation of BE studies can spell correctly?
Why even a cross-over at all if
Take 5 groups with 3 subjects each (makes 15 in total
) treat them with the 5 doses and make your assessment of dose linearity via descriptive stats? Is this what you have in mind?
Downright silly if two subjects from the same group drop out
.
don't get your point.
Why do you favour a Williams design (balanced or not) BEman has in mind over a simpler Latin square design as I suggested or a much simpler incomplete block design with less periods than treatments which Helmut suggested as one possibility, which BTW addresses your concern "the risk of dropouts"?
Why do you think this is a "... big theoretical problem ..."? Because its more unusual and lesser known then what's called Williams design everybody who had some notation of BE studies can spell correctly?
Why even a cross-over at all if
❝ much of the info about linearity in current EU SPCs and US Prescr infos are based on simply descriptive stats from designs with parallel groups or xo.
Take 5 groups with 3 subjects each (makes 15 in total
) treat them with the 5 doses and make your assessment of dose linearity via descriptive stats? Is this what you have in mind?Downright silly if two subjects from the same group drop out
.—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- 5x5-crossover study with 12 subjects - sequences beman 2012-03-12 14:23
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 5x5-crossover study with 12 subjects - sequences ElMaestro 2012-03-12 14:55
- 5x5-crossover study with 12 subjects - sequences Dr_Dan 2012-03-12 15:25
- 5x5-crossover study with 12 subjects - sequences beman 2012-03-12 15:38
- 5x5-crossover study with 12 subjects - sequences Dr_Dan 2012-03-13 10:59
- 5x5-crossover study with 12 subjects - sequences beman 2012-03-12 15:38
- 5x5-crossover study with 12 subjects - sequences Helmut 2012-03-12 22:31
- 12 d_labes 2012-03-13 10:32
- 5x5-crossover study with 12 subjects - sequences ElMaestro 2012-03-13 11:47
- Questions over questionsd_labes 2012-03-13 13:08
- ok then lemme explain ElMaestro 2012-03-13 13:26
- ok then lemme explain d_labes 2012-03-13 15:03
- Questions over questions ElMaestro 2012-03-13 15:45
- ok then lemme explain ElMaestro 2012-03-13 13:26
- 5x5-crossover study with 12 subjects - sequences beman 2012-03-13 13:12
- Questions over questionsd_labes 2012-03-13 13:08
- 5x5-crossover study with 12 subjects - sequences beman 2012-03-13 13:25
Ing. Helmut Schütz