Bioequivalence and Bioavailability Forum • 5x5-crossover study with 12 subjects

5x5-crossover study with 12 subjects - sequences [Regulatives / Guidelines]

posted by beman – 2012-03-12 15:23 (5222 d 14:42 ago) – Posting: # 8250
Views: 7,655

Dear all,

i try to generate sequences for a 5x5-crossover study including 12 subjects.

Using Wiliams-Desing i need 10 sequences, but i have only 12 subjects, so it is not possible to have a balanced design.

Do you have any idea how to solve the problem ? Using 4 or 5 sequences with the disadvantage of an unblanced design ? How can i minimize the disadvantage ?

Thank you

Best regards

beman

Complete thread:

5x5-crossover study with 12 subjects - sequencesbeman 2012-03-12 14:23
- 5x5-crossover study with 12 subjects - sequences ElMaestro 2012-03-12 14:55
- 5x5-crossover study with 12 subjects - sequences Dr_Dan 2012-03-12 15:25
  - 5x5-crossover study with 12 subjects - sequences beman 2012-03-12 15:38
    - 5x5-crossover study with 12 subjects - sequences Dr_Dan 2012-03-13 10:59
- 5x5-crossover study with 12 subjects - sequences Helmut 2012-03-12 22:31
  - 12 d_labes 2012-03-13 10:32
  - 5x5-crossover study with 12 subjects - sequences ElMaestro 2012-03-13 11:47
    - Questions over questions d_labes 2012-03-13 13:08
      - ok then lemme explain ElMaestro 2012-03-13 13:26
        
        ok then lemme explain d_labes 2012-03-13 15:03
      - Questions over questions ElMaestro 2012-03-13 15:45
    - 5x5-crossover study with 12 subjects - sequences beman 2012-03-13 13:12
  - 5x5-crossover study with 12 subjects - sequences beman 2012-03-13 13:25