Bioequivalence and Bioavailability Forum

Another Oops. [Regulatives / Guidelines]

posted by Helmut  – Vienna, Austria, 2011-11-25 15:23 (5326 d 14:43 ago) – Posting: # 7724
Views: 10,369

Dear Detlew!

❝ Inspecting it I have some doubts:

❝ ❝ […] some nonsense code

❝

❝ Must the EMA guidance interpreted in this way, i.e. analysing the dataset with 'pseudo' periods and sequences? Or should it interpreted the way which is employed in the Q&A for the replicate design (intra-subject variability of the reference). That means only massacre out the data concerning R2 but retaining the original periods and sequences.

Exactly! Should forget copypasting old code when new ‘knowledge’ became available in the meantime.

❝ ❝ FMMSE     <- summary(FullModel)$sigma^2/FMdf

❝ At least the code for FMMSE has stolen my sleep . According to the help page of lm.summary() "... sigma - the square root of the estimated variance of the random error" and IMHO then the MSE is sigma^2 without the division by the degrees of freedom!

Oh s**t!

❝ Check this out via anova(FullModel)["Residuals","Mean Sq"]==summary(FullModel)$sigma^2 .

❝ Or did I miss sumfink here?

No, no. Sorry!

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Anticonservativism?! ElMaestro 2010-02-06 17:10 
  • Conservativism? Helmut 2011-11-03 21:12
    • In hindsight... ElMaestro 2011-11-03 21:43
      • In hindsight... Helmut 2011-11-04 01:56
        • In hindsight... ElMaestro 2011-11-04 08:41
        • rlnorm simulates what? d_labes 2011-11-04 09:40
          • Oops. Helmut 2011-11-04 16:05
            • Oops. ElMaestro 2011-11-04 16:22
              • Simulation of intra-subject variability d_labes 2011-11-07 11:16
                • Simulation of intra-subject variability ElMaestro 2011-11-08 11:02
            • Oops. Oops. d_labes 2011-11-25 13:54
              • Another Oops.Helmut 2011-11-25 14:23
  • Simul Ants questions d_labes 2011-11-04 15:46
    • Simul Ants questions ElMaestro 2011-11-04 16:06
    • Simul Ants questions Helmut 2011-11-04 16:09
  • Liberal Conservatives d_labes 2011-11-08 11:31
    • Liberal Conservatives martin 2011-11-08 20:50
      • Liberal Conservatives Helmut 2011-11-08 22:56
        • intra-subject correlation martin 2011-11-09 09:01
          • intra-subject correlation Helmut 2011-11-25 17:16