Bioequivalence and Bioavailability Forum • PHX/WNL vs. SAS

PHX/WNL vs. SAS [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2011-10-08 04:21 (5377 d 09:52 ago) – Posting: # 7449
Views: 16,375

Comrades!

❝ ❝ The SE and 90%CI for R and T are not equal within WNL and SAS, which will be reliable? (Even for equal sequences data)

❝

❝ Wow! That's curious.

Mistery solved (?) after this post.

untransformed
PHX/WNL 6.2
fixed: sequence+formulation+period random: sub(sequence) Treatment LSM SE LowerCI UpperCI 1 235.1521 12.7463 213.1332 257.1711 2 231.8667 12.7463 209.8477 253.8856 -------------------------------------------------------- Estimate StdError P_value LowerCI UpperCI 1 - 2 3.2854762 10.387277 0.75644 -15.009737 21.580689 fixed: sequence+formulation+period+sub(sequence) Treatment LSM SE LowerCI UpperCI 1 235.1521 7.34491 222.2155 248.0888 2 231.8667 7.34491 218.9300 244.8033 -------------------------------------------------------- Estimate StdError P_value LowerCI UpperCI 1 - 2 3.2854762 10.387277 0.75644 -15.009737 21.580689

SAS
fixed: sequence+formulation+period random: sub(sequence) Treatment LSM SE LowerCI UpperCI 1 235.1521 7.34491 222.2155 248.0888 2 231.8667 7.34491 218.9300 244.8033 -------------------------------------------------------- Estimate StdError P_value LowerCI UpperCI 1 - 2 3.2855 10.3873 0.7564 -15.0097 21.5807
ln-transformed
PHX/WNL 6.2
fixed: sequence+formulation+period random: sub(sequence) Treatment LSM SE LowerCI UpperCI 1 5.4356405 0.0563377 5.3386689 5.5326121 2 5.4265687 0.0563377 5.3295970 5.5235403 ------------------------------------------------------ Estimate StdError P_value LowerCI UpperCI 1 - 2 0.009072 0.0513393 0.8623 -0.081353 0.099496 fixed: sequence+formulation+period+sub(sequence) Treatment LSM SE LowerCI UpperCI 1 5.435641 0.0363024 5.371701 5.499580 2 5.426569 0.0363024 5.362629 5.490508 ------------------------------------------------------ Estimate StdError P_value LowerCI UpperCI 1 - 2 0.009072 0.0513393 0.8623 -0.081353 0.099496

SAS
fixed: sequence+formulation+period random: sub(sequence) Treatment LSM SE LowerCI UpperCI 1 5.435641 0.0363024 5.371701 5.499580 2 5.426569 0.0363024 5.362629 5.490508 ------------------------------------------------------ Estimate StdError P_value LowerCI UpperCI 1 - 2 0.009072 0.0513393 0.8623 -0.081353 0.099496

If you want to get in PHX/WNL the same LSMs/SE/CIs of treatments as in SAS you have to set all effects fixed.

Maybe you can try SAS’ Proc MIXED instead of Proc GLM and tweak it in order to give you LSMEANS similar to PHX/WNL.
But I’m not equipped with …

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Complete thread:

Least Square Means (LSM) for unequal sequence yicaoting 2011-10-03 14:37
- Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 14:51
  - Least Square Means (LSM) for unequal sequence yicaoting 2011-10-03 15:28
    - Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 15:36
    - Least Square Means (LSM) for unequal sequence Helmut 2011-10-03 16:14
      - Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 20:10
  - Least Square Means (LSM) for unequal sequence Pankaj Bhangale 2011-10-04 14:52
    - Weighted Means? Helmut 2011-10-05 01:53
- LSM for unbalanced sequences -SAS- d_labes 2011-10-04 09:39
  - LSM for unbalanced sequences -SAS- yicaoting 2011-10-04 19:37
    - SE for unbalanced sequences SAS vs. WinNonlin Helmut 2011-10-05 01:01
    - LS Means mean? d_labes 2011-10-05 12:45
      - LS Means mean? ElMaestro 2011-10-05 13:23
      - PHX/WNL vs. SASHelmut 2011-10-08 02:21
        
        PHX/WNL vs. SAS Proc Mixed d_labes 2011-10-10 15:46
        
        PHX/WNL vs. SAS Proc Mixed Helmut 2011-10-10 16:30
        
        PHX/WNL vs. SAS Proc Mixed ElMaestro 2011-10-10 19:53
        
        Real mixed effects in WNL, SAS, GLM or Mixed (1) yicaoting 2011-10-13 18:39
        Real mixed effects in WNL, SAS, GLM or Mixed (2) yicaoting 2011-10-13 18:52
        Real mixed effects in WNL, SAS, GLM or Mixed (3) yicaoting 2011-10-13 19:05
        
        Must admit I am lost ElMaestro 2011-10-14 00:02
        
        Must admit I am lost yicaoting 2011-10-14 06:30
        
        Must admit I am lost - edited ElMaestro 2011-10-14 13:23