Bioequivalence and Bioavailability Forum • Weighted Means?

Weighted Means? [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2011-10-05 03:53 (5378 d 21:01 ago) – Posting: # 7425
Views: 16,657

Dear Pankaj,

personally I have great sympathy for your procedure (suggesting a weighted mean). With yicaoting’s data of formulation 1 we would get:

(238.92·7 + 231.38·9)/(7+9) = 234.68

Unfortunately both SAS and Phoenix/WinNonlin report only the LSM (238.92 + 231.38)/2 = 235.15 (which is required in many guidelines). No big deal if sequences are not too unbalanced.
I think your suggestion is reasonable but you open a can of worms (see also this post and ElMaestro’s reply).

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Complete thread:

Least Square Means (LSM) for unequal sequence yicaoting 2011-10-03 14:37
- Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 14:51
  - Least Square Means (LSM) for unequal sequence yicaoting 2011-10-03 15:28
    - Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 15:36
    - Least Square Means (LSM) for unequal sequence Helmut 2011-10-03 16:14
      - Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 20:10
  - Least Square Means (LSM) for unequal sequence Pankaj Bhangale 2011-10-04 14:52
    - Weighted Means?Helmut 2011-10-05 01:53
- LSM for unbalanced sequences -SAS- d_labes 2011-10-04 09:39
  - LSM for unbalanced sequences -SAS- yicaoting 2011-10-04 19:37
    - SE for unbalanced sequences SAS vs. WinNonlin Helmut 2011-10-05 01:01
    - LS Means mean? d_labes 2011-10-05 12:45
      - LS Means mean? ElMaestro 2011-10-05 13:23
      - PHX/WNL vs. SAS Helmut 2011-10-08 02:21
        
        PHX/WNL vs. SAS Proc Mixed d_labes 2011-10-10 15:46
        
        PHX/WNL vs. SAS Proc Mixed Helmut 2011-10-10 16:30
        
        PHX/WNL vs. SAS Proc Mixed ElMaestro 2011-10-10 19:53
        
        Real mixed effects in WNL, SAS, GLM or Mixed (1) yicaoting 2011-10-13 18:39
        Real mixed effects in WNL, SAS, GLM or Mixed (2) yicaoting 2011-10-13 18:52
        Real mixed effects in WNL, SAS, GLM or Mixed (3) yicaoting 2011-10-13 19:05
        
        Must admit I am lost ElMaestro 2011-10-14 00:02
        
        Must admit I am lost yicaoting 2011-10-14 06:30
        
        Must admit I am lost - edited ElMaestro 2011-10-14 13:23