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RegisterCalcium stable isotope [Regulatives / Guidelines]
posted by Helmut 
– Vienna, Austria, 2011-05-04 13:50 (5535 d 14:01 ago) – Posting: # 6992
Views: 2,346
Dear PM,
please check with the sponsor which kind of formulations he wants to test. For calcium acetate FDA requires in vitro data only (tablet, capsule).
If you really want to go with an in vivo study, consider the body pool of ≈40 µg 46Ca and the narrow normal range of calcium concentrations due to homeostasis. I have some doubts whether you will “see” a relevant change even after a high dose.
please check with the sponsor which kind of formulations he wants to test. For calcium acetate FDA requires in vitro data only (tablet, capsule).
If you really want to go with an in vivo study, consider the body pool of ≈40 µg 46Ca and the narrow normal range of calcium concentrations due to homeostasis. I have some doubts whether you will “see” a relevant change even after a high dose.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Calcium stable isotope ClinResBE 2011-05-04 11:13
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Calcium stable isotopeHelmut 2011-05-04 11:50
Ing. Helmut Schütz