Bioequivalence and Bioavailability Forum

Dear maverick
I do not know where you want to do the study, but in the ethical guideline of ICMR has defined this

1. from healthy adults and non-pregnant women who weigh normal for their age and not more than 500 ml blood is drawn in an 8 week period and frequency of collection is not more than 2 times per week;
   
2. from other adults and children, where the age, weight, and health of the participants, the collection procedure, the amount of blood to be collected, and the frequency with which it will be collected has been considered and not more than 50 ml or 3 ml per kg, whichever is lesser is drawn in an 8 week period and not more than 2 times per week;

And also very important, as discussed depends on the ethics committee which provides approval for the protocol.
Ethics may deny the permission if it exceeds the limit specified and you have to relook into the time points of the draw and frequency of washout period also.

Regards
Suds

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Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post!
@Maverick: You find the document (3.1MB!) at the Guideline Collection; the section quoted by Suds is at p14. [Jaime]