Bioequivalence and Bioavailability Forum • Outlier (tests?)

Outlier (tests?) [Regulatives / Guidelines]

posted by earlybird – 2010-02-09 17:45 (5985 d 05:39 ago) – Posting: # 4739
Views: 7,067

Dear HS,

❝ Almost. TPD wants a test of the studentised residuals

Ok sometimes the small words inbetween are important i.e. "of"

❝ ❝ What about Hotelings T²

❝

❝ Well, that's a multivariate test; what do you want to test here?

This was a suggestion from one of your's previous posts

❝ ❝ Cooks distance, Mahalanobis distance,

❝

❝ Exploratory only, i.e., no tests.

❝

❝ ❝ robust regression,

❝

❝ On what?

ok, I have to check, that again

❝ ❝ Lund' test?

❝

❝ Obsolete, I would say.

❝

❝ ❝ Are these "studentised residual" tests?

❝

❝ As said above we should test the studentised residuals; there's no "studentised residual test".

❝ For identification I use to plot the studentised intra-subject residual vs. the model response and had only two additional reference lines based on the normal distribution (0.05), i.e. at ±1.960. For 0.02 that would transfer to ±2.326. I'm not sure what TPD means by 'degrees of freedom for the design'. Most likely the one of the residual error (n₁+n₂-2 in 2×2 cross-over).

❝ Examples: n=24, t_0.02,22 2.508, n=36 t_0.02,34 2.441. But that's no test; multiplicity issues are ignored (can they?)...

so all in all you mean

1. I should ask the Canadian what they mean exactly
2. Wait until the guideline is final?

Greetings,
earlybird

Complete thread:

Canada: Draft Guidances published Helmut 2010-01-28 00:52
- Outlier earlybird 2010-02-09 08:35
  - Outlier (tests?) Helmut 2010-02-09 14:55
    - Outlier (tests?)earlybird 2010-02-09 16:45
      - Outlier (tests?) Helmut 2010-02-09 17:05
        
        Outlier (tests?) earlybird 2010-02-09 17:18
        Outlier "im Quadrat" d_labes 2010-02-10 13:51
        
        Hotelling's T² Helmut 2010-02-11 17:56
    - Lund! d_labes 2010-02-10 13:36
      - Lund! Helmut 2010-02-12 20:04
        
        intercept ElMaestro 2010-02-12 20:29
        
        intercept Helmut 2010-02-13 00:03
        
        intercept ElMaestro 2010-02-13 01:04
        
        Lund's critical values, technically d_labes 2010-02-22 12:52
        
        R code ElMaestro 2010-02-25 14:22
        
        R code quest d_labes 2010-02-25 16:34
        
        R code quest ElMaestro 2010-02-25 17:06