Bioequivalence and Bioavailability Forum • Sample size partial replicate design

Sample size partial replicate design [Regulatives / Guidelines]

posted by d_labes – Berlin, Germany, 2010-01-07 14:56 (6017 d 19:09 ago) – Posting: # 4573
Views: 7,665

Dear Helmut,

once again: Where does the sample size come from?
Can you please explain in a little bit more detail? df, design constant, exact or with non-central t? Or sample size for 2x2 multiplied by 0.75?

Don't call me obtrusive nitpicker :wink:

. I'm interested in including this design (RRT, RTR, TRR, a 2-treatment-3-sequence-3-period design) into my "eierlegende wollmilchsau" but have not found any hint about sample size for ABE within that design up to now.
Do you have any reference for me?

—
Regards,

Detlew

Complete thread:

Scaled Average Bioequivalence graveendranath 2010-01-06 07:36
- RSABE (EU) Helmut 2010-01-06 17:01
  - RSABE (EU) d_labes 2010-01-07 09:14
    - RSABE (EU) Helmut 2010-01-07 13:21
      - Sample size partial replicate designd_labes 2010-01-07 13:56
        
        Sample size partial replicate design Helmut 2010-01-07 14:23
        
        Sample size partial replicate design: df d_labes 2010-01-07 16:21
        Sample size partial replicate design: variance d_labes 2010-01-08 10:37