Bioequivalence and Bioavailability Forum

Hi John,

❝ I tried the first option in Phoenix and I received an error related to Satterthwaite... I will try the 2nd option and see.

As the others already pointed out, option 2 is the way to go. See the second example in this article.
Say, subject 1 is randomized to sequence \(\small{\text{ACBD}}\). In Phoenix (as well as in in SAS) you need a flat file structure. Therefore, for this subject you should drop the data of periods 1 and 3 (i.e., treatments A and B) and code:$$\small{\begin{array}{c|cccc}
\textsf{subject} & \textsf{period} & \textsf{sequence} & \textsf{treatment} & \textsf{PK}\\\hline
1 & 2 & \text{ACBD} & \text{C} & foo\\
1 & 4 & \text{ACBD} & \text{D} & bar\\
\cdots & \cdots & \cdots & \cdots & \cdots\\
\end{array}}$$