Bioequivalence and Bioavailability Forum • Beyond Bonferroni…

Beyond Bonferroni… [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2025-11-10 09:56 (220 d 05:20 ago) – Posting: # 24482
Views: 1,889

Hi BEQool,

❝ Has anyone ever used Holm-Bonferroni alpha adjustment method? I am wondering if any agency had any questions about it.

❝ Additionally, has anyone ever used Hommel alpha adjustment method? Namely it is more powerful than Holm-Bonferroni method.

Not me (none of them).
Maybe you are interested in the EMA workshop on multiplicity issues in clinical trials of 2012, esp. the presentation by Jiří Hofmann (Zentiva) and the discussion by Thomas Lang (AGES and at that time member of the BSWP).
If you have some stamina and really nothing better to do, watch the recording at the end of the page. I got the impression that anything beyond Bonferroni is not what regulators like. Given, 13 years ago.

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Complete thread:

ICHM13A/Multiple Test Product Studies Mikkabel 2025-11-04 09:46
- α-adjustments? Helmut 2025-11-04 11:15
  - α-adjustments? Mikkabel 2025-11-04 12:03
    - α-adjustments? BEQool 2025-11-09 20:08
      - Beyond Bonferroni…Helmut 2025-11-10 08:56