Bioequivalence and Bioavailability Forum • Population BE [PBE]

Population BE [PBE] [Regulatives / Guidelines]

posted by ElMaestro – Denmark, 2025-01-06 13:52 (137 d 05:30 ago) – Posting: # 24324
Views: 2,154

Hi jdfr,

❝ I believe that I can extract MSB and MSW from an ANOVA. Is that correct?

That would in principle be correct, I think. however if you ask me there is no reason to do so since the guidance (stop 2) directly gives the equations on how to calculate these quantities.

❝ What I am struggling the most is with calculating the components for point and confidence interval estimation (table after step 4). Should I compute them one by one, or is there any package / analysis technique from which I can extract these components. I am not really familiarized with those notations.

I do not know of a package that does it for you. There may be smarter ways of doing it, but in my implementation I build / calculate the rows on the tables one by one and at the end all there's left is just a bit of summation to do. I follow strictly the calculation suggested in the guidance. To do so I need to understand the meaning of the notation.

—
Pass or fail!
ElMaestro

Complete thread:

Population BE [PBE] jdfr 2024-12-05 16:34
- Population BE [PBE] ElMaestro 2024-12-17 22:50
  - Population BE [PBE] jdfr 2025-01-06 11:14
    - Population BE [PBE]ElMaestro 2025-01-06 12:52
      - Population BE [PBE] jdfr 2025-01-07 12:08
        
        Population BE [PBE] ElMaestro 2025-01-07 13:50
        
        Population BE [PBE] jdfr 2025-01-07 17:10
        
        Population BE [PBE] ElMaestro 2025-01-07 18:55
        
        Population BE [PBE] jdfr 2025-01-08 10:13
        
        Population BE [PBE] ElMaestro 2025-01-08 11:02
        
        Population BE [PBE] jdfr 2025-01-08 17:45
        Population BE [PBE] jdfr 2025-01-09 09:16
        
        Population BE [PBE] ElMaestro 2025-01-09 14:46