Bioequivalence and Bioavailability Forum

Hello Helmut/All,

I have question regarding outlier test (Using Lund's method) for reference replicate crossover study design.

How can we find outlier? which one will be appropriate scenario for any regulatory point of view?

Scenario 1 : can we use test and individual reference (R R) to calculate standardized residual?

Scenario 2 : Can we use test and average of reference (average of R R) to calculate standardized residual?




Thanks in advance!