Bioequivalence and Bioavailability Forum • tmax IR

tmax IR > tmax MR? [Regulatives / Guidelines]

posted by jag009 – NJ, 2016-01-29 23:51 (3802 d 16:15 ago) – Posting: # 15898
Views: 4,946

Hi Dr.Dan,

❝ Is there a possibility that tmax of the IR formulated drug is greater than tmax of the MR formulated?

For MR product emesis criteria we would base on the dosing interval (ie, once daily then 24 hr) and not the Tmax. I assume the original post "XR" means MR product?

Thanks
John

Complete thread:

multilayer tablet exclusion criteria from PK analysis due to emesis Mahesh M 2016-01-08 10:56
- multilayer tablet exclusion criteria from PK analysis due to emesis Mahesh M 2016-01-13 12:46
  - multilayer tablet exclusion criteria from PK analysis due to emesis jag009 2016-01-26 17:56
    - tmax IR > tmax MR? Dr_Dan 2016-01-28 08:57
      - tmax IR > tmax MR?jag009 2016-01-29 22:51
- multilayer tablet exclusion criteria from PK analysis due to emesis Shuanghe 2016-01-28 13:00
  - multilayer tablet exclusion criteria from PK analysis due to emesis jag009 2016-01-29 23:02
    - multilayer tablet exclusion criteria from PK analysis due to emesis Shuanghe 2016-02-01 11:01
      - multilayer tablet exclusion criteria from PK analysis due to emesis Mahesh M 2016-02-01 13:14