Bioequivalence and Bioavailability Forum • Pharmacokinetics linearity

Pharmacokinetics linearity [Regulatives / Guidelines]

posted by nobody – 2015-05-28 15:44 (4051 d 00:51 ago) – Posting: # 14866
Views: 5,470

❝ 3. If Cmax and AUC data are available for the dose 25 mg and 50mg and lndose vs lnAUC pass through 0 can linearity be assumed for 5 mg also?

OMG! General principles of linear regression: Never extrapolate beyond your data range actually measured.

What kind of science is that here? :-o

—
Kindest regards, nobody

Complete thread:

Pharmacokinetics linearity pjs 2015-05-20 10:25
- Pharmacokinetics linearity pjs 2015-05-28 12:26
  - Pharmacokinetics linearitynobody 2015-05-28 13:44
    - Pharmacokinetics linearity ElMaestro 2015-05-28 14:14
      - Pharmacokinetics linearity Dr_Dan 2015-05-28 14:32
        
        Pharmacokinetics linearity pjs 2015-05-28 14:58
        
        Pharmacokinetics linearity nobody 2015-05-28 15:50
        
        Pharmacokinetics linearity pjs 2015-05-28 16:11
        
        Pharmacokinetics linearity Dr_Dan 2015-05-29 09:03

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