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Registerparabens influence on bioavailability [Regulatives / Guidelines]
Hi Dr_Dan
I do not have any practical experience on this but I have read an article where paraben acted by inhibiting the metabolism pattern of some of the prodrugs. "Coincubation of tenofovir DF with this mixture also resulted in an enhancement of its absorption in the in vitro Caco-2 system as well as in rat ileum" Full test is available here
Also this one is worth reading "A study on the absorption mechanism of drugs through biomembranes"
Hope this would be of some help.
Regards
❝ Does by chance anybody know if for a generic test formulation a difference in the content of parabens in comparison to an oral liquid reference formulation could have an influence on bioavailability/bioequivalence of a drug?
I do not have any practical experience on this but I have read an article where paraben acted by inhibiting the metabolism pattern of some of the prodrugs. "Coincubation of tenofovir DF with this mixture also resulted in an enhancement of its absorption in the in vitro Caco-2 system as well as in rat ileum" Full test is available here
Also this one is worth reading "A study on the absorption mechanism of drugs through biomembranes"
Hope this would be of some help.
Regards
—
~A happy Soul~
~A happy Soul~
Complete thread:
- parabens influence on bioavailability Dr_Dan 2015-02-05 14:24
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- parabens influence on bioavailabilityluvblooms 2015-02-19 05:59
- parabens influence on bioavailability nobody 2015-02-19 08:57
- parabens influence on bioavailabilityluvblooms 2015-02-19 05:59
Ing. Helmut Schütz