MDIs formulation [Regulatives / Guidelines]

posted by Mahesh M – India, 2014-12-11 14:45 (4219 d 15:42 ago) – Posting: # 14054
Views: 4,128

Dear All,

Can anyone suggest me what are the reasons for maintaining 30 sec gap between two inhalation (Puffs) in MDIs formulation? (Mentioned in SPC or PI)
And if we maintained the 30 sec gap between two puffs then chances miss to characterize the initial rate of absorption of the drug and the peak concentrations.

Regards

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