Bioequivalence and Bioavailability Forum • Four studies with the same formulation

Four studies with the same formulation [Regulatives / Guidelines]

posted by jag009 – NJ, 2014-02-11 21:01 (4522 d 10:58 ago) – Posting: # 12407
Views: 10,568

24 tables? wt*

❝ Maybe some of the tablets did not release the drug immediatelly, causing a retard effect that affected the second period data, or something like that.

Possible, in one study we dosed 4x100 mg tablets and one subject data was weird (low concentration).

❝ Besides that, someone mentioned to me a "Memory effect", in which the human body learns how to deal with the drug, causing a different reaction at the second administration. I personally think that this is very hard to happen at only 1 single dose administration.

I doubt that. Too sci-fi for me.

John

Complete thread:

Sequence Effect on Endogenous Drugs Lucas 2014-02-10 20:01
- Sequence Effect on Endogenous Drugs ElMaestro 2014-02-10 20:09
  - Sequence Effect on Endogenous Drugs Lucas 2014-02-11 12:24
    - Sequence Effect on Endogenous Drugs ElMaestro 2014-02-11 13:26
      - Sequence Effect on Endogenous Drugs Lucas 2014-02-11 17:38
- Sequence Effect on Endogenous Drugs jag009 2014-02-10 21:35
  - Sequence Effect on Endogenous Drugs Lucas 2014-02-11 12:28
    - Sequence Effect on Endogenous Drugs jag009 2014-02-11 17:21
      - Sequence Effect on Endogenous Drugs Lucas 2014-02-11 17:33
- Sequence Effect on Endogenous Drugs Helmut 2014-02-11 15:07
  - Curious jag009 2014-02-11 17:16
  - Sequence Effect on Endogenous Drugs Lucas 2014-02-11 17:45
- Four studies with the same formulation Lucas 2014-02-11 17:32
  - Four studies with the same formulationjag009 2014-02-11 20:01