Bioequivalence and Bioavailability Forum

Hi Angus,

❝ In future I think I will round my exact times to two decimals, since I think that is enough. I will then perform PK data analysis using the rounded numbers.

❝

❝ Do agree that 2 decimals for times is OK...yes?

I feel that if sampling times are recorded to ±1 minute rounding hours to two decimals is too “granular”. Time is the independent variable in PK, so I would not apply aggressive rounding. Another idea: Use minutes rather than hours for time. In Phoenix you can have an additional column keeping hours in full precision. Calculate AUCs as [minutes × mass / volume] and divide just once at the end by 60. In the tables show minutes and in the plots use the hour-column. What ’bout that?