Bioequivalence and Bioavailability Forum

calculation of Washout period [Regulatives / Guidelines]

posted by bharathnadh.pharma – India, 2014-01-18 10:45 (4542 d 00:56 ago) – Posting: # 12193
Views: 24,023

Dear Dr. Dan,

Yes sir it helps to me and here is my own clarification about time points
For example: Drug a having elimination half-life (t1/2) ranged from 8-16 hours and tmax of about 1.5-4 hours.
Generally we take more than 3 elimination half-life’s so here I took 5.
Half-life=8-16, average 12hrs, 12*5=60hrs based on this I took sample points as shown in below.
0.00, 0.50, 1.00, 1.50, 2.00, 2.50, 3.00, 3.50, 4.00, 4.50, 5.00, 6.00, 8.00, 10.00, 12.00, 16.00, 24.00, 36.00 and 48.00
In these samples up to 4.50 I took half an hour samples because of Tmax.
My calculation is correct are not. Please guide me.

thanks in advance

---

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]

Complete thread:

• calculation of Washout period bharathnadh.pharma 2014-01-17 09:48 
  • calculation of Washout period Dr_Dan 2014-01-17 11:48
    • calculation of Washout period Mahesh M 2014-01-17 12:26
      • calculation of Washout period jag009 2014-01-17 17:41
      • calculation of Washout period drgunasakaran1 2014-01-17 17:59
        • calculation of Washout period Mahesh M 2014-01-20 10:46
        • calculation of Washout period rezowan 2014-01-23 19:13
          • Theoretical carry-over Helmut 2014-01-23 19:57
            • Theoretical carry-over bharathnadh.pharma 2014-01-25 17:33
    • calculation of Washout periodbharathnadh.pharma 2014-01-18 09:45
      • calculation of Washout period drgunasakaran1 2014-01-18 15:37
        • calculation of Washout period bharathnadh.pharma 2014-01-20 05:44
          • calculation of Washout period Ohlbe 2014-01-20 06:37