Bioequivalence and Bioavailability Forum • Prep-Run in Bioanalytical

Prep-Run in Bioanalytical [Regulatives / Guidelines]

posted by Ohlbe – France, 2013-10-23 14:59 (4626 d 14:17 ago) – Posting: # 11734
Views: 4,074

Dear Kumar,

First, and once again: please read this post. When answering a message, please delete everything from the text of the original poster which is not necessary in understanding your answer.

❝ So system suitability alone can not stabilize the MS system right?

Are you using aqueous samples for system suitability, or plasma-based samples ? If aqueous or solvent-based: no, it will not stabilise the system. If plasma-based: maybe it will, maybe it won't be sufficient. Some methods will require only a few injections, sometimes you need a few dozens.

❝ We may need to have prep-run procedure in place?

If you are using prep runs: yes, if you want to avoid the problems that Cetero ran into.

—
Regards
Ohlbe

Complete thread:

Prep-Run in Bioanalytical riteshsrmc 2013-10-17 08:21
- Prep-Run in Bioanalytical sarada06884 2013-10-17 11:50
  - Prep-Run in Bioanalytical riteshsrmc 2013-10-17 13:50
    - Prep-Run in Bioanalytical sarada06884 2013-10-18 07:07
      - Prep-Run in Bioanalytical riteshsrmc 2013-10-18 07:49
        
        Prep-Run in Bioanalytical Ohlbe 2013-10-18 14:29
        
        Prep-Run in Bioanalytical riteshsrmc 2013-10-23 12:28
        
        Prep-Run in BioanalyticalOhlbe 2013-10-23 12:59
        
        Prep-Run in Bioanalytical riteshsrmc 2013-10-23 13:13