Bioequivalence and Bioavailability Forum • CL of CV

CL of CV [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2013-09-06 17:02 (4673 d 12:13 ago) – Posting: # 11451
Views: 8,859

Hi Jay,

❝ […] guide in calculation of upper confidence limit of the CV.

I would suggest to get package PowerTOST for R. Easy with Kumar’s data (CV_w 24.64% in 52 subjects):

require(PowerTOST) CVCL(CV=0.2464, df=52-2, side="upper")

which gives:

lower CL upper CL 0.0000000 0.2974387

If you want to walk the stony path of manual calculation:

\({s_{w}}^{2}=\log{({CV_{w}}^{2}+1)}=\log{(0.2464^2+1)}=0.05894\).
In a 2×2 cross-over where n is the total number of subjects: ν = n – 2
\(\alpha=0.05 \to \chi_{\alpha,\nu}^{2}=34.764\).
\(CL_{upper}=\sqrt{e^{{\sigma_{w}}^{2}\cdot\nu/\chi_{\alpha,\nu}^{2}}-1}=\sqrt{e^{0.05894\times50/34.764}-1}={\color{DarkGreen}{0.2974\sim29.7\%}}\).

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Complete thread:

Sample size vasup 2013-07-29 08:37
- Sample size ElMaestro 2013-07-29 10:00
- Sample size jag009 2013-07-29 15:57
- Overpowering Helmut 2013-07-30 15:51
  - Overpowering ElMaestro 2013-07-30 16:37
    - Overpowering jag009 2013-07-30 16:45
      - Overpowering ElMaestro 2013-07-30 16:51
        
        Overpowering jag009 2013-08-01 20:08
        
        Overpowering kumarnaidu 2013-09-02 12:22
        
        Conservative study planning Helmut 2013-09-02 12:42
        
        Conservative study planning kumarnaidu 2013-09-02 14:36
        
        Conservative study planning Ohlbe 2013-09-02 18:44
        
        confidence limit of the CV Jay 2013-09-06 13:55
        
        CL of CVHelmut 2013-09-06 15:02
        
        CL of CV Jay 2013-09-06 15:21
        
        CL of CV Helmut 2013-09-06 15:42
        
        PE consideration Jay 2013-09-11 11:02
        
        PE consideration Dr_Dan 2013-09-11 12:07
        
        PE consideration Jay 2013-09-11 13:09
        PE consideration kumarnaidu 2013-09-11 13:22
        
        Sockpuppet? Helmut 2013-09-11 14:13
        PE consideration kumarnaidu 2013-09-12 13:04

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